The comic detailed the adventures of debutante Phoebe Zeit-Geist as she was variously kidnapped and rescued by a series of bizarre characters, such as Nazis, Chinese foot fetishists, and lesbian assassins. For the majority of the strip, the title character was drawn in the nude, and subject to a number of tortures, humiliations and even multiple deaths.
Doonesbury comic-strip creator Garry Trudeau cited the strip as an early inspiration, saying, "[A] very heavy influence was a serial in the Sixties called 'Phoebe Zeitgeist'. . . . It was an absolutely brilliant, deadpan send-up of adventure comics, but with a very edgy modernist kind of approach. To this day, I hold virtually every panel in my brain. It's very hard not to steal from it."