The human skull used as the base for the work, bought in a shop in Islington, is thought to be that of a European living between 1720 and 1810. The work's title was supposedly inspired by Hirst's mother, who once asked, “For the love of God, what are you going to do next?”
8,601 flawless pavé-laid diamonds, weighing in total 1,106.18 carats (221.24 g), over a platinum cast, cover the entirety of the skull, with the exception of the original teeth of the skull. At the centre of the forehead lies a pear-shaped pink diamond, the centrepiece of the work. All diamonds used for the work are said to be ethically sourced.