There were four episodes made by Justin Roiland, each about five minutes. An unofficial fifth episode was also made.
It was first aired on the internet television channel Channel 101, and was the first of Channel 101's programs to spend three consecutive months at number 1.
The cartoon, which is based loosely on a true story, features main character Mitchell Reynolds (voiced by Jeff Davis) who invents a cloning machine in order to create his own personal Bill Cosby to entertain him. He then begins cloning several more Cosbys to help him around the house, much like in the plot of the 1996 film Multiplicity. However, the quality of the clones seems to deteriorate as the process is repeated, and he decides to stop using the machine, but when one of the clones subversively activates it, he discovers that every tenth Cosby he clones has super powers. At the suggestion of Data Analysis Cosby (the first super-powered Cosby) they decide to continue cloning Cosbys so that their super powers can be used to help the world.
House of Cosbys was cancelled when series creator Justin Roiland and Channel 101's site administrator Dan Harmon received a cease and desist letter from Bill Cosby's attorney in June 2005. One of the issues under contention is whether House of Cosbys is covered under the fair use, as parody. Supporters point out that many TV shows like Family Guy and The Simpsons have used Cosby's likeness, and have not been sued. However, there also is the factor that House of Cosbys used risque subject matter not in accordance with Cosby's character and comedy.
As a result of the cease and desist letter, the fifth episode was created by a different contributor and functioned primarily as an attack on Bill Cosby and his attorney.